Job Description
Principal Research Scientist, Protein Sciences
Overview:
We are seeking an exceptional Senior Scientist or Principal Scientist to join the Protein Sciences group within Lead Discovery at a fast-growing biotechnology company developing innovative cancer therapeutics. This scientist will play a pivotal role in advancing oncology discovery programs by leading recombinant protein production, purification, and characterization efforts for complex therapeutic targets. The ideal candidate is a technically outstanding protein scientist who thrives on solving difficult expression and purification challenges. This individual will help shape strategy, execute high-impact experiments, and expand internal protein sciences capabilities that support structural biology, biochemical, and biophysical discovery efforts. This is an opportunity to contribute directly to the discovery of next-generation cancer therapies while working in a collaborative, fast-moving research environment.
Industry : Lead Discovery
Location : South San Francisco, CA
Compensation : $75-$95 per hour (based upon experience)
$156,000-$197,600 per annum (based upon experience)
Type : Full-time (12-month Contract, possibility of extension based on performance)
Key Responsibilities: - Design and lead recombinant protein expression and purification strategies for challenging therapeutic targets, including optimization and scale-up (10 L or larger).
- Develop and execute advanced chromatography workflows using affinity, ion exchange, and size exclusion purification on AKTA FPLC systems.
- Innovate and implement strategies to successfully express and purify complex or difficult protein targets.
- Lead scientific troubleshooting for challenging protein production campaigns.
- Contribute to analytical characterization efforts to evaluate protein purity, stability, and functionality.
- Support and help expand the organization’s protein sciences platform and capabilities.
- Collaborate closely with structural biology, biochemistry, medicinal chemistry, and translational research teams to deliver high-quality protein reagents for discovery programs.
- Present experimental strategies, interpret results, and provide scientific insight in cross-functional team discussions.
- Influence project strategy and contribute to decisions that advance therapeutic programs.
- Foster a culture of scientific rigor, collaboration, and innovation.
Qualifications:
- Ph.D. in Biochemistry, Molecular Biology, Biology, or a related discipline.
- Approximately 3–6 years of post-graduate experience in protein expression and characterization.
- Demonstrated scientific productivity, including peer-reviewed publications.
- Extensive hands-on experience with recombinant protein expression across multiple systems, including bacterial, insect, mammalian, and/or yeast platforms.
- Deep expertise in protein purification and chromatography workflows, particularly using AKTA FPLC systems.
- Strong experience with protein characterization techniques, such as SDS-PAGE, SEC, DLS, DSF, MALS, LC-MS, and NMR.
- Proven ability to independently design experiments, troubleshoot complex challenges, and deliver results.
- Excellent communication skills with the ability to collaborate and influence across multidisciplinary teams.
Estimated Min Rate : $66.50
Estimated Max Rate : $95.00
What’s In It for You?
We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:
- Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
- Health Savings Account (HSA) (for employees working 20+ hours per week)
- Life & Disability Insurance (for employees working 20+ hours per week)
- MetLife Voluntary Benefits
- Employee Assistance Program (EAP)
- 401K Retirement Savings Plan
- Direct Deposit & weekly epayroll
- Referral Bonus Programs
- Certification and training opportunities
Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.
Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Visit to contact us if you are an individual with a disability and require accommodation in the application process.
For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.
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Job Tags
Hourly pay, Full time, Contract work